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Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract:

In this paper, the study on family collection, gene mapping, gene identification and gene functiont (1; 3) (q44; p11) associated with nasopharyngeal cancer was found in 1975 at first, and human TDF geneIn 1998, GJB3, a human genetic neurological deafness gene, was identified using a novel strategy of “Gene Family-Candidate Disease Gene Cloning”，and the paper was published in Nature Geneticswas also cloned from gene function study.

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan     gene function study    

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Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: To investigate the regulation of tumor suppressor XAF1 gene expression in digestive system cancers, westudied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell linesand human embryonic kidney 293 cells [HEK293 cells]) as controls. 1395-bp-promoter fragment of XAF1 gene

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

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GAIN OF FRUIT NETTED-CRACKING IN AN INTROGRESSION LINE OF TOMATO WITH HIGHER EXPRESSION OF THE FNC GENE

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: population was generated by crossing IL4-4 with M82 to genetically characterize the FNC geneand this showed that a single dominant gene determined fruit netted-cracking.Further map-based cloning narrowed down the FNC locus to a 230 kb region on chromosomeSequencing and annotation analysis show that FNC(Solyc04 g082540) was the most likely candidate gene

Keywords： fine mapping / fruit netted-cracking / introgression line / transcript level    

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Chemical mapping of cement pastes by using confocal Raman spectroscopy

Fengjuan LIU,Zhihui SUN

Frontiers of Structural and Civil Engineering 2016, Volume 10, Issue 2,   Pages 168-173 doi: 10.1007/s11709-015-0323-9

Abstract: In the present study, chemical mapping on the hydration process of cement paste with water-to-cementIt is concluded from the study that chemical mapping was an effective method to assist in visualizing

Keywords： chemical mapping     Raman spectroscopy     calcium silicates     calcium hydroxide     ettringite    

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Independent continuous and mapping method of structural topology optimization based on the global stress

Yunkang SUI, Jili FENG, Hongling YE, Xirong PENG,

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 2,   Pages 130-142 doi: 10.1007/s11465-010-0011-3

Abstract: four measures are adopted. 1) Topology optimization model is established by independent continuous mapping

Keywords： independent continuous mapping (ICM) method     global stresses constraints     topology optimization     continuum    

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cDNA Cloning of Neuropeptide Y gene of turbot Scophthalmus maximus L. and its expression analysis of

Han Jian,Liu Bin,Jiang Zhiqiang,Mu Xiaosheng,Lei Jilin

Strategic Study of CAE 2014, Volume 16, Issue 9,   Pages 42-49

Abstract:

In this study, the full length of turbot NPY cDNA was cloned using RT-PCR and rapid-amplification of cDNA ends (RACE). Turbot NPY cDNA is 729bp with a 5´-untranslated region (UTR), 135bp 3´-UTR and 299bp ORF. The open reading frame encodes a 99 amino acid NPY. The first 28 amino acids constitute the signal sequence followed by the 36 amino acid mature peptide. Turbot NPY share a 53.9–98.0% identity with NPY from other fish, especially, Turbot NPY share a 97–98.0% identity with NPY from other flounder (Japanese flounder, winter flounder).Using real-time PCR to analysis NPY expression in turbot. Tissue distribution studies show that NPY mRNA is expressed in brain, in particular the hypothalamic, and in peripheral tissues. During food deprivation, the NPY undergo significant change in expression (P<0.05), with NPY levels being elevated first, then decreased, and being significantly increased, maintain a high level of expression, then decreased again during food deprivation. Expression level was significantly higher with refeeding after fasting than the normal feeding, the longer of food deprivation, the higher of expression level. But the expression level of 2h after refeeding will fall again to a similar level. Our results suggest that NPY is conserved peptides that might be involved in the regulation of feeding and other physiological functions in turbot.

Keywords： Turbot (Scophthalmus maximus L.) Neuropeptide Y Starvation Feeding Differential expression    

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A survey of photon mapping state-of-the-art research and future challenges

Chun-meng KANG,Lu WAN,Yan-ning XU,Xiang-xu MENG

Frontiers of Information Technology & Electronic Engineering 2016, Volume 17, Issue 3,   Pages 185-199 doi: 10.1631/FITEE.1500251

Abstract: The photon mapping algorithm is an effective method for computing global illumination with its obviousThe deficiency of precise details and efficient rendering are still the main challenges of photon mappingof categories including radiance estimation, photon relaxation, photon tracing, progressive photon mappingThe goals of our report are giving readers an overall introduction to photon mapping and motivating further

Keywords： Global illumination     Photon mapping     Radiance estimation     Photon relaxation     Progressive photon mapping    

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and future research directions for the phytoremediation of heavy metal-contaminated soil: A knowledge mapping

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 6, doi: 10.1007/s11783-021-1507-2

Abstract:

• The overall global perspective of the PHMCS field was obtained.

Keywords： Heavy metal-contaminated soil     Hot topics     Knowledge mapping analysis     Knowledge base     Phytoremediation    

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Factors affecting early embryonic development in cattle: relevance for bovine cloning

Yanna DANG, Kun ZHANG

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 33-41 doi: 10.15302/J-FASE-2018228

Abstract: Incomplete epigenetic reprogramming is believed to be a major limitation to cloning efficiency.., Trichostatin A) could greatly improve cloning efficiency in both mice and cattle.

Keywords： bovine cloning     embryo development     somatic cell nuclear transfer     X-inactive specific transcript    

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Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 663-675 doi: 10.1007/s11705-017-1623-5

Abstract: Small interfering RNA (siRNA) therapeutics hold great promise to treat a variety of diseases, as long as they can be delivered safely and effectively into cells. Dendrimers are appealing vectors for siRNA delivery by virtue of their well-defined molecular architecture and multivalent cooperativity. However, the clinical translation of RNA therapeutics mediated by dendrimer delivery is hampered by the lack of dendrimers that are of high quality to meet good manufacturing practice standard. In this context, we have developed small amphiphilic dendrimers that self-assemble into supramolecular structures, which mimic high-generation dendrimers synthesized with covalent construction, yet are easy to produce in large amount and superior quality. Indeed, the concept of supramolecular dendrimers has proved to be very promising, and has opened up a new avenue for dendrimer-mediated siRNA delivery. A series of self-assembling supramolecular dendrimers have consequently been established, some of them out-performing the currently available nonviral vectors in delivering siRNA to various cell types and , including human primary cells and stem cells. This short review presents a brief introduction to RNAi therapeutics, the obstacles to their delivery and the advantages of dendrimer delivery vectors as well as our bio-inspired structurally flexible dendrimers for siRNA delivery. We then highlight our efforts in creating self-assembling amphiphilic dendrimers to construct supramolecular dendrimer nanosystems for effective siRNA delivery as well as the related structural alterations to enhance delivery efficiency. The advent of self-assembling supramolecular dendrimer nanovectors holds great promise and heralds a new era of dendrimer-mediated delivery of RNA therapeutics in biomedical applications.

Keywords： gene therapy     RNAi therapeutics     dendrimer     nanovectors     gene silencing    

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Electromagnetic induction mapping at varied soil moisture reveals field-scale soil textural patterns

Hiruy ABDU, David A. ROBINSON, Janis BOETTINGER, Scott B. JONES

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 2,   Pages 135-145 doi: 10.15302/J-FASE-2017143

Abstract: Our objective was to employ electromagnetic induction (EMI) mapping in low apparent electrical conductivity

Keywords： soil electrical conductivity     soil texture mapping     temporal stability analysis    

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Quantifying and mapping spatial variability of Shanghai household carbon footprints

Shangguang YANG,Chunlan WANG,Kevin LO,Mark WANG,Lin LIU

Frontiers in Energy 2015, Volume 9, Issue 1,   Pages 115-124 doi: 10.1007/s11708-015-0348-8

Abstract: Understanding the spatial variability of household carbon emissions is necessary for formulating sustainable and low-carbon energy policy. However, data on household carbon emissions is limited in China, the world’s largest greenhouse gases emitter. This study quantifies and maps household carbon emissions in Shanghai using a city-wide household survey. The findings reveal substantial spatial variability in household carbon emissions, especially in transport-related emissions. Low emission clusters are founded in Hongkou, Xuhui, Luwan, Jinshan, and Fengxian. High emission clusters are located in Jiading and Pudong. Overall, the spatial pattern of household carbon emissions in Shanghai is donut-shaped: lowest in the urban core, increasing in the surrounding suburban areas, and declining again in the urban fringe and rural regions. The household emissions are correlated with a number of housing and socioeconomic factors, including car ownership, type of dwelling, size of dwelling, age of dwelling, and income. The findings underscore the importance of a localized approach to low-carbon policy-making and implementation.

Keywords： household carbon emissions     spatial variability     energy policy     Shanghai     China    

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The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 161-168 doi: 10.1007/s11684-017-0531-x

Abstract: We propose that the resistance gene flow in nature is “from the natural environments” andand animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene

Keywords： antibiotic resistance     resistome     microbiome     gene flow    

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Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 211-217 doi: 10.15302/J-FASE-2019303

Abstract: functions regarding economic traits, and new materials for livestock breeding have been obtained through geneEvaluation is the most important component of the regulation of gene-edited livestock and is a crucialguarantee of public safety before the marketing of gene-edited animal products.Here, the system of evaluation of gene-edited livestock is discussed in terms of public safety and production

Keywords： evaluation     gene editing     livestock     performance     safety    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Then, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signatureThis study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Title Author Date Type Operation

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

GAIN OF FRUIT NETTED-CRACKING IN AN INTROGRESSION LINE OF TOMATO WITH HIGHER EXPRESSION OF THE FNC GENE

Journal Article

Chemical mapping of cement pastes by using confocal Raman spectroscopy

Fengjuan LIU,Zhihui SUN

Journal Article

Independent continuous and mapping method of structural topology optimization based on the global stress

Yunkang SUI, Jili FENG, Hongling YE, Xirong PENG,

Journal Article

cDNA Cloning of Neuropeptide Y gene of turbot Scophthalmus maximus L. and its expression analysis of

Han Jian,Liu Bin,Jiang Zhiqiang,Mu Xiaosheng,Lei Jilin

Journal Article

A survey of photon mapping state-of-the-art research and future challenges

Chun-meng KANG,Lu WAN,Yan-ning XU,Xiang-xu MENG

Journal Article

and future research directions for the phytoremediation of heavy metal-contaminated soil: A knowledge mapping

Journal Article

Factors affecting early embryonic development in cattle: relevance for bovine cloning

Yanna DANG, Kun ZHANG

Journal Article

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Journal Article

Electromagnetic induction mapping at varied soil moisture reveals field-scale soil textural patterns

Hiruy ABDU, David A. ROBINSON, Janis BOETTINGER, Scott B. JONES

Journal Article

Quantifying and mapping spatial variability of Shanghai household carbon footprints

Shangguang YANG,Chunlan WANG,Kevin LO,Mark WANG,Lin LIU

Journal Article

The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Journal Article

Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article